Associação entre a exposição a desreguladores endócrinos e desenvolvimento de doença hepática gordurosa não alcóolica / Association between exposure to endocrine deregulators and development of non alcoholic fat hepatic disease

Authors

  • Letícia Felipe Félix Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Elaine Barros Ferreira
  • Priscilla Roberta Silva Rocha

DOI:

https://doi.org/10.34117/bjdv6n3-260

Keywords:

“Disruptores Endócrinos”, “Exposição Ambiental”, “Fígado Gorduroso”.

Abstract

Estudos têm revelado a relação entre a exposição a compostos ambientais e o desenvolvimento de danos hepáticos. Objetivo: identificar evidências de associação entre a exposição humana aos desreguladores endócrinos e a ocorrência de desenvolvimento de doença hepática gordurosa não alcoólica. Método: revisão integrativa de literatura, as buscas foram realizadas nas bases de dados eletrônicas Cochrane, PubMed, LILACS, e Science Direct. Foram incluídos estudos primários em humanos, que abordaram o desfecho de interesse, sem restrição temporal, publicados em inglês, português ou espanhol. Resultados: de 209 artigos identificados, 12 foram selecionados, todos em língua inglesa, sendo 50% estudos transversais, 33% de coorte e 16% de casos-controle. A mensuração da exposição aos desreguladores endócrinos ocorreu por meio da análise de amostras de urina, sangue ou solo. A exposição ao Bisfenol A e Trialometanos foi associada à ocorrência de acúmulo de gordura hepática, especialmente em indivíduos obesos, do sexo masculino e de origem hispânica. Conclusão: os achados desta revisão evidenciam a associação entre exposição a desreguladores endócrinos  e a ocorrência de danos hepáticos,  indicando a necessidade do desenvolvimento de estratégias para evitar a exposição sobretudo em pacientes de maior risco.

 

 

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Published

2020-03-17

How to Cite

Félix, L. F., Ferreira, E. B., & Rocha, P. R. S. (2020). Associação entre a exposição a desreguladores endócrinos e desenvolvimento de doença hepática gordurosa não alcóolica / Association between exposure to endocrine deregulators and development of non alcoholic fat hepatic disease. Brazilian Journal of Development, 6(3), 13239–13261. https://doi.org/10.34117/bjdv6n3-260

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Section

Original Papers