Eficácia dos inibidores da dipeptidil peptidase 4 (DPP-4) para o tratamento da diabetes mellitus 2 / Efficacy of dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus

Karinne Nancy Sena Rocha, Bruna Magalhães Pereira, Iago Ladeia Costa, Giullia Gonçalves Fabri, Camilla Negrão Wilhans, Letícia Fagundes Lemos, Marlon Ramos Rosado Machado, Marcela Sales De Lucca Rodrigues

Abstract


As terapias à base de peptídeo semelhante ao glucagon 1, como os inibidores da dipeptidil peptidase 4, agonistas do receptor de GLP-1, afetam o controle da glicose por meio de mecanismos, incluindo aumento da secreção de insulina dependente de glicose, lentidão gástrica esvaziamento e redução do glucagon pós-prandial e da ingestão de alimentos. Os inibidores da DPP-4 podem ser considerados como monoterapia em pacientes com diabetes tipo 2 que são intolerantes ou têm contraindicações à metformina ou outros agentes redutores da glicose. Os inibidores da DPP-4 podem ser considerados como terapia medicamentosa adicional para pacientes que são inadequadamente controlados com metformina , uma tiazolidinediona, inibidor do co-transportador 2 de sódio-glicose ou uma sulfonilureia. Os inibidores DPP-4 parecem ter eficácia glicêmica semelhante, eles resultam em uma melhora modesta na hemoglobina glicada. 


Keywords


Diabetes Mellitus, Inibidores da Dipeptidil Peptidase IV, Eficácia.

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DOI: https://doi.org/10.34119/bjhrv5n1-026

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