Overlap syndrome of systemic lupus erythematosus and systemic sclerosis in a person living with HIV: the paradox of immunodeficiency and autoimmunity coming together / Síndrome de overlap entre lupus eritematoso sistêmico e esclerose sístemica em pessoa vivendo com HIV: o paradoxo da imunodeficiência e autoimunidade

Gabriel Pacifico Seabra Nunes, Isabela Mota de Almeida, Gabriela Dalmazo Garcia Barreto, Monique Rodrigues Pereira Pinto, Hemilly da Silva Pires, Natacha Helena Uryu, Simone Ferreira de Castro Botileiro, Sandra Lucia Euzebio Ribeiro

Abstract


The existence of autoimmune dysfunction in HIV/AIDS patients is intriguing. Many cases are being reported around the world of the combination of HIV with systemic autoimmune diseases. We report a case of an HIV-infected patient that presented alopecia, symmetric polyarthritis, skin thickening and raynaud’s phenomenon. Diagnosis of overlap syndrome of SS and SLE was made and treatment with prednisone, methotrexate and nifedipine started. No HIV flare was documented.


Keywords


HIV, systemic sclerosis, systemic lupus erythematosus, autoimmune diseases.

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References


Zandman-Goddard G, Shoenfeld Y. HIV and Autoimmunity. Autoimmun Rev, 2002; 1(6): 329-37

Okong’o LO, Webb K, Scott C. HIV-associated juvenile systemic sclerosis: A case report. Semin Arthritis Rheum, 2015; 44 (4): 411-6.

Sikdar S, Grover C, Kubba S, Yadav A, Sahni V, Aggarwal G et al. An uncommon cause of scleroderma. Scand J Rheummatol, 2005; 34 (3): 242-5

Vega LE, Espinoza LR. HIV infection and it’s effects on the development of autoimmune disorders. Pharmacol Res, 2018; 129: 1-9

Fox C, Walker-Bone K. Evolving Spectrum of HIC-Associated Rheumatic Syndromes. Best Pract Res Clin Rheumatol, 2015; 29(2): 244-58

Carreiro FT, Betkova S, Sepúlved C, Manata MJ, Cardoso O, Maltez F et al. Immunodeficiency and autoimmunity coming together: a nearly missed diagnosis. Lupus, 2017; 27(3): 511-3

Roszkiewicz J, Smolewska E. Kaleidoscope of autoimmune diseases in HIV infection. Rheumatol Int, 2016; 36(11):1481-91

Carugati M, Franzetti M, Torre A, Giorgi R, Genderini A, Castilla FS et al. Systemic lupus erythematosus and HIV infection: a whimsical relationship. Report of two cases and review of the literature. Clin Rheumatol, 2013’ 32(9): 1399-405

López-López L, González A, Vilá LM. Long-term membranous glomerulonephritis as the presenting manifestation of systemic lupus erythematosus in a patient with human immunodeficiency virus infection. Lupus, 2012; 21(8): 900-4

Belgaumkar VA, Chavan RB, Surcyataley PR, Salunke AS, Patil PP, Borade SM. Systemic lupus erythematosus in HIV: An insight into clinical implications and management. Indian J Sex Transm Dis AIDS, 2019; 40(1): 64-66




DOI: https://doi.org/10.34119/bjhrv5n3-039

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