Evaluation of the rotavirus vaccine introduced into infant population in the semiarid region of the state of Paraíba, Brazil (2006 - 2013) / Avaliação da vacina para rotavírus introduzida na população infantil do semiárido paraibano (2006 - 2013)

Marcelo Moreno, Fernando Portela Câmara

Abstract


Acute gastroenteritis caused by rotavirus represents a clinical episode of great relevance to Brazilian public health due to its expressive mortality rate in children under five years of age. In Brazil, Rotarix® from GlaxoSmithKline, a live attenuated vaccine, has been used in children since 2006. The present study evaluated the effectiveness of vaccination in the semiarid region of Paraíba, a Brazilian state, through the notification of diarrhea cases, clinical data of the disease in the period from 2005 to 2013, and the detection of viral antigens in the feces of hospitalized children in the years 2012 and 2013. There was no significant reduction in the number of cases of diarrhea with the implementation of vaccination in the period studied, with an epidemic of diarrhea in 2013, when the number of cases increased 4 times compared to the previous period


Keywords


rotavirus, vaccine, rotarix, infantile diarrhea.

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References


ARAÚJO, Eliete da Cunha, et al. Safety, immunogenicity, and protective efficacy of two doses of RIX4414 live attenuated human rotavirus vaccine in healthy Brazilian infants. Journal Pediatric (Rio de Janeiro), v. 83, p. 217-224, 2007. Disponível em: http://www.scielo.br/pdf/jped/v83n3/v83n3a06.pdf. DOI: 10.2223/JPED.1600. Acesso em: 13 nov. 2016.

BLACK, Robert E., et al: Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet, v. 375, n. 9730, p.1969–1987, 2010.

BRANCO, Fernando Luiz Cunha Castelo et al. Socioeconomic inequalities are still a barrier to full child vaccine coverage in the Brazilian Amazon: a cross-sectional study in Assis Brasil, Acre, Brazil. International Journal for Equity in Health, v. 13, p.118, 2014. Disponível em: http://www.equityhealthj.com/content/13/1/118. DOI: 10.1186/s12939-014-0118-y. Acesso em: 10 nov. 2016.

CILLI, Audrey et al. Characterization of rotavirus and norovirus strains: a 6-year study (2004-2009). Journal Pediatric (Rio de Janeiro), v. 87, n. 5, p. 445-449, 2011. Disponível em: http://www.scielo.br/pdf/jped/v87n5/v87n05a13.pdf. DOI:10.2223/JPED.2122. Acesso em: 17 nov. 2016.

COMITÊ INTERNACIONAL DE TAXONOMIA DE VÍRUS (ICTV). https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsrna-viruses 2011/w/dsrna_viruses/188/reoviridae. Acesso em: 04 set 2018.

CORTESE, Margaret M et al. Effectiveness of monovalent and pentavalent rotavirus vaccine. Pediatrics, v. 132, n. 1, p. 25-33, 2013. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074617/pdf/peds.2012-3804.pdf. DOI: 10.1542/peds.2012-3804. Acesso em: 09 ago. 2016

DENNIS, Allison F et al. Molecular Epidemiology of Contemporary G2P[4] Human Rotaviruses Cocirculating in a Single U.S. Community: Footprints of a Globally Transitioning Genotype. Journal Virology, v. 88, n. 7, p. 3789-3801, 2014. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC3993531/pdf/zjv3789.pdf. DOI:10.1128/JVI.03516-13. Acesso em: 20 set. 2016.

ESTES, Mary K. ; KAPIKIAN, Albert Z. Rotaviruses. In: Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (editors). Fields virology, 6th ed. Vol 2. Lippincott Williams & Wilkins, Philadelphia, PA; p. 1347–401, 2013.

GLADSTONE, Beryl P. et al. Protective Effect of Natural Rotavirus Infection in an Indian Birth Cohort. New England Journal Medicine, v. 28; n. 365(4), p. 337–346, 2011. Disponível em: http://www.nejm.org/doi/pdf/10.1056/NEJMoa1006261 DOI: 10. 1056/NEJMoa1006261. Acesso em: 13 nov. 2016.

LUCHS, Adriana et al. Rotavirus in adults, Brazil, 2004–2011: G2P[4] dominance and potential impact on vaccination. Brazilian Journal Infectious Diseases, v. 18, n. 1, p.53–59, 2014. Disponível em: http://www.scielo.br/pdf/bjid/v18n1/1413-8670-bjid-18-01-0053.pdf. DOI: 10.1016/ j.bjid.2013.05.010. Acesso em: 13 nov. 2016.

MORENO, Marcelo. Estudo Termodinâmico da Estabilidade de Rotavirus nos Estados Úmido e Seco. 2001. 86f. Tese (Doutorado em Ciências [Microbiologia/Imunologia]). Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro. 2001.

NÓBREGA Jr., Alex Carneiro da Cunha et al. Avaliação da Eficácia da Vacina Rotarix®-GlaxoSmithKline Biologicals, no Período de 2006 a 2010 no Municipio de Cuité, na Região do Curimataú Paraibano, Brasil. In: II CONGRESSO NORTE-NORDESTE DE CIÊNCIAS FARMACÊUTICAS. João Pessoa, Paraíba; 2011.

O’RYAN, Miguel. Rotarix™ (RIX4414): an oral human rotavirus vaccine. Expert Review Vaccines, v.6, n.1, p.11–19, 2007. Disponível em : http://www.slipe.org/pdf/Rotarix%20(RIX4414)%20an%20oral%20human%20rotavirus%20vaccine.pdf. DOI: 10.1586/14760584.6.1.11. Acesso em: 02 set. 2017.

PETER, G; MYERS, Martin G. Intussusception, rotavirus, and oral vaccines: summary of a workshop. Pediatrics, v. 110, p. 67, 2002. Disponível em: http://pediatrics. aappublications.org/content/pediatrics/110/6/e67.full.pdf DOI: 10.1542/ peds. 111. 2.449-a. Acesso em: 02 dez. 2016.

ROSE, Tatiana Lundgren et al. Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010. Emergent Infectious Disease, v.19, n.11, p.1843-1846, 2013. Disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837663/pdf/12-1407.pdf. DOI: 10.3201/eid1911.121407. Acesso em: 02 ago. 2016.

SANTOS, Norma; Hoshino, Yasutaka. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Review Medical Virology, v. 15, n.1, p.29-56, 2005. Disponível em: http://onlinelibrary.wiley.com/doi/10.1002/rmv.448/pdf. DOI: 10.1002/rmv.448. Acesso em: 02 jul. 2016.

TATE, Jacqueline E. et al. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infectious Disease, v.12, n.2, p.136-141, 2011. Disponível em: http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(11) 70253-5.pdf. DOI: 10.1016/S1473-3099(11)70253-5. Acesso em: 02 set. 2016.

ZLAMY, Manuela et al. The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections. BMC Infectious Diseases, n.13, p.112, 2013. Disponível em: http://www.biomedcentral.com/1471-2334/13/112. DOI: 10.1186/1471-2334-13-112. Acesso em: 02 nov. 2016. Acesso em: 27 set. 2016.




DOI: https://doi.org/10.34119/bjhrv5n3-061

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