Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature

Yasmin Melo Toledo, Maria Nathalia Prado Simões Mendonça, Marina de Pádua Nogueira


Neuroendocrine tumor of the uterine cervix is a rare malignant neoplasm, ranging from 0.5 to 5% of uterine cervix cancers.  Most of the cases occur in women younger (average 43 years) than those with the usual histologic types.  It may occasionally be found associated with spindle cell carcinoma (SCC) and with adenocarcinoma (AC).  The relationship between neuroendocrine tumor and human papillomavirus (HVP), specially the high-risk 16 and 18, is demonstrated in several studies.  The diagnosis is definitive through the use of histologic hematoxyline-eosine staining, however identification of chromogranin, synaptophysin and enolase by immunohistochemistry plays an important role in the diagnostic doubt.  The high tumor aggressiveness is demonstrated by the high percentage of lymph node impairment and early hematogenic invasion at the moment of diagnosis, 68% and 90%, respectively.  Survival is short, with an average of 22 months.  Multimodal treatment is the most frequently described form.


neuroendocrine carcinoma, cervical câncer.


ABELER, Vera; HOLM, Ruth; NESLAND, Jahn; KJØRSTAD, Kjell. Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. Cancer 1994; 73:672.

ALBORES-SAAVEDRA, Jorge et al. Carcinoid of the uterine cervix: additional observations on a new tumor entity. Cancer 1976; 3 :2328.

ALBORES-SAAVEDRA, Jorge et al. Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med 1997; 121:34.

CASTLE, Philip; PIERZ, Amanda; STOLER, Mark. A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix. Gynecol Oncol 2018; 148:422.

CHAN, Jhon; LOIZZI, Vera; BURGER, Robert; RUTGERS, Joanne; MONK, Bradley. Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. Cancer. 2003;97(3):568-74.

GARDNER, Ginger; REIDY-LAGUNES, Diane; GEHRIG, Paola. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol 2011; 122:190.

HORN, Lars-Christian; LINDNER, Kristin; SZEPANKIEWICZ, Grit et al. p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix. 2006;25(2):182-6.

ISHIDA, Gabriela Mirei; KATO, Noriko; HAYASAKA, Tadashi et al. Small cell neuroendocrine carcinomas of the uterine cervix: a histological, immunohistochemical, and molecular genetic study. Int J Gynecol Pathol. 2004;23(4):366-72.

LEE, JM; LEE, KB; NAM, JH et al. Prognostic factors in FIGO stage IB-IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: results of a multi-center retrospective Korean study. Ann Oncol 2008; 19:321.

MCCUSKER, Margareth; COTÉ, Timothy; CLEGG, Limin; TAVASSOLI, Fattaneh. Endocrine tumors of the uterine cervix: incidence, demographics, and survival with comparison to squamous cell carcinoma. Gynecol Oncol 2003; 88:333..

NIWA, Kenji; NONAKA-SHIBATA, Mayuko; SATOH, Eriko; HIROSE, Yoshiyuki. Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report. Acta Cytol. 2010;54(5 Suppl):977-80.

REAGAN et al. Analytical study of the cells in cervical squamous-cell cancer. Lab Invest 1957; 6:241.

SCHMIDT; HORN; KOMMOSS. Neuroendocrine carcinomas of the cervix. Pathologe. 2005;26(4):262-5.

VISWANATHAN, Akila N; DEAVERS, Michael T; JHINGRAN, Anuja et al. Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecol Oncol 2004; 93:27.

WANG, Kung-Liahng; YANG, Yuh-Cheng; WANG, Tao-Yeuan et al. Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother 2006; 18:209.



  • There are currently no refbacks.