The maternal western diet exacerbates the inflammatory response in the offspring, but does not alter the action of the non-steroidal anti-inflammatory drug/ Dieta ocidentalizada materna exacerba a resposta inflamatória na prole, mas não altera a eficácia da ação de droga anti-inflamatória não esteroidal

Authors

  • Nathalia Caroline de Oliveira Melo Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Nathália Cavalcanti de Morais Araújo
  • Alexandra Rabello Freire
  • Maria Bernadete de Souza Maia
  • Elizabeth do Nascimento

DOI:

https://doi.org/10.34117/bjdv7n1-683

Keywords:

Drug Therapy, Gestation, Inflammation, Lactation, Offspring, Westernized diet.

Abstract

Objective: To evaluate the impacte of the maternal diet, used since the pre-gestational period, on the inflammatory and metabolic process of offspring after aggressive stimulus and the pharmacological efficacy os treatment with nimesulide. Methodology: Eighteen Wistar rats were divided into 3 groups according to dietary treatment (control diet/ westernized diet) and their descendants were analyzed according to maternal dietary intervention and pharmacological treatment with nimesulide, forming six subgroups. The following parameters were evaluated: weight evolution, food intake, biochemical parameters, lipid and leukocyte infiltration in the liver and level of antioxidante enzyme and inflammatory cytokines. Results: At 60 days of age, the offspring of mothers fed a westernized diet, especially those exposed to a westernized diet until weaning, presented hyperglycemia, greater waist circunference, length and body weight; as high total leukocyte count, IL-6, TNF-?, and greater lipid and leukocyte infiltrate in the liver (p<0,05). Conclusion: The adoption of a westernized diet by rats of reproductive age and continued during pregnancy and/ or lactation alters the nutritional status in the long term and produces na exacerbated inflammatory state arise from na agressive stimulus, but does not interfere in the efficacy of the response of the pharmacological treatment.

References

- NAZNI P. Association of western diet & lifestyle with decreased fertility. Indian J Med Res. 2014;140,78-81.

- COELHO NLP. Food consumption and birth weight. Rev Saúde Pública. 2015;49-62.

- FERRO CAVALCANTE TC, MARCELINO DA SILVA AA, LIRA MC, DO AMARAL ALMEIDA LC, MARQUES AP, DO NASCIMENTO E. Effects of a westernized diet on the reflexes and physical maturation of male rat offspring during the perinatal period. Lipids. 2013;48:1157-68.

– DO NASCIMENTO E, MUNIZ GS, MARCELINO DA SILVA AA, SANTANA RA, VASCONCELOS DAA, FERRO CAVALCANTI TC. Western-style diet changes murinometric and metabolic parameters of rat offspring in time-specific windows. Braz J of Develop. 2020; 6(7):48355-372.

- MARTINS E SILVA J, SALDANHA C. Diet, atherosclerosis and atherothrombotic events. Rev Port Cardiol. 2007;26(3):277-94.

- TAHERIPOUR P. Impact of excess gestational and post-weaning energy intake on vascular function of swine offspring. BMC Pregnancy Childbirth. 2014;4:405.

- VIDAL-SANTOS R. et al. Western diet in the perinatal period promotes dysautonomia in the offspring of adult rats. J Dev Orig Health Dis. 2017;8(2):216-25.

- TAIN YL, et al. Maternal melatonin therapy rescues prenatal dexamethasone and post-natal high fat diet induced programmed hypertension in male rat offspring. Front Physiol. 2015;6:377.

- PEI X, LIU L, CAI Y, PENG Y, MA C, JIN Y. Body mass index cut-off points for predicting chronic non-communicable disease should differ by gender and age group. Public Health. 2019;175:54-59.

- BULLÓ M, et al. Systemic Inflammation, Adipose Tissue Tumor Necrosis Factor, and Leptin Expression. Obes Res. 2003;11(4).

- SIRIWARDHANA N, et al.Modulation of adipose tissue inflammation by bioactive food compounds. J Nutr Biochem. 2013;24(4):613-23.

- NASCIMENTO CMO, RIBEIRO EB, OYAMA LM. Metabolism and secretory function of white adipose tissue: effect of dietary fat. An Acad Bras Cienc. 2009;81(3).

- SILVA LA, VEIRA-FILHO LD, BARRETO IS, CABRAL EV, VIEYRA A, PAIXÃO AD. Prenatal undernutrition changes renovascular responses of nimesulide in rat kidneys. Basic Clin Pharmacol Toxicol. 2011;108(2):115-21.

- MINISTÉRIO DA CIÊNCIA, TECNOLOGIA E INOVAÇÃO. Regimento Interno do Conselho Nacional de Controle de Experimentação Animal. PORTARIA Nº 460, DE 30 DE ABRIL DE 2014. Disponível em: http://www.mctic.gov.br/mctic/opencms/institucional/concea/Destaques/oquee.html. Acesso em: 13/-3/2019 às 13h40m.

- Guide for the Care and Use of Laboratory Animals (Eighth Edition, 2011, published by The National Academies Press, 2101 Constitution Ave. NW, Washington, DC 20055, USA.

- ANDRADE A, PINTO SC, OLIVEIRA RS. Animais de Laboratório: criação e experimentação [online]. Rio de Janeiro: Editora FIOCRUZ. 2002. p.388.

- LEVIN BE, TRISCARI E, SULLIVAN AC. Metabolic features of diet-induced obesity without hyperphagia in young rats. Am J Regul integr Comp Physiol. 1986;251(3):433-440.

- HOWLAND RD, MYCE MJ. Farmacologia Ilustrada. 3a edição. Rio Grande do Sul: Artmed Editora S.A. 2007.

- MENEZES TM. Impactos da dieta “ocidentalizada” durante a gestação e lactação na resposta inflamatória aguda e suas implicações na eficácia farmacológica da nimesulida na prole adulta de ratos Wistar. [Dissertação]. Pernambuco: Universidade Federal de Pernambuco, 2016.

- KUMAR V, ABBAS AK, FAUSTO N. Robbins e Cotran: Patologia: bases patológicas das doenças. 7 ed. São Paulo: Elsevier, 2005.

- NOVELLI ELB, et al. Anthropometrical parameters and markers of obesity in Rats. Lab Anim Res. 2007;41:111-19.

- MUSIAL B. et al. A Western?style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. J Physiol. 2017;595(14):4875-92.

- RIBAROFF GA, WASTNEDGE E, DRAKE AJ, SHARPE RM, CHAMBERS TJG. Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis. Obes Rev. 2017;18(6):673-86.

- NICHOLAS LM, RATTANATRAY L, MORRISON JL, KLEEMANN DO, WALKER SK, ZHANG S, et al. Maternal obesity or weight loss around conception impacts hepatic fatty acid metabolism in the offspring. Obes. 2014;22(7):1685-93

- SUTER M, BOCOCK P, SHOWALTER L, HU M, SHOPE C, McKNIGHT R, et al. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. FASEB J. 2011;25(2);714–26.

- BAUTISTA CJ, MONTAÑO S, RAMIREZ V, et al. Changes in milk composition in obese rats consuming a high-fat diet. Br J Nutr. 2016;538–546.

- SIMINO LAP , FANTE T, FONTANA MF, BORGES FO, TORSONI MA, MILANSKI M, et al. Lipid Overload During Gestation and Lactation Can Independently Alter Lipid Homeostasis in Offspring and Promote Metabolic Impairment After New Challenge to High-Fat Diet. Nutr Metab. 2017;20:14:16.

- DESAI M, HAN G,ROSS MG. Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators. Appetite. 2016;1:99:193-199

- PHAM DL, et al. What we know about nonsteroidal anti-inflammatory drug hypersensitivity. Korean J Intern Med. 2016;31(3):417-32.

- SOUSA JM, NETO FMA, PARTATA AK. Ação anti-inflamatória da nimesulida e seu grau de hepatotoxicidade. Revista Científica do ITPAC. 2016;9(1).

- KALUPAHANA NS, MOUSTAID?MOUSSA N, CLAYCOMBE KJ. Immunity as a link between obesity and insulin resistance. Mol Aspects Med. 2012;33:26?34.

- CALDER PC, ALBERS R, ANTOINE JM et al. Inflammatory disease pro? cesses and interactions with nutrition. Br J Nutr. 2009;101(1):1–4.

- PRIEUR X, MOK CY, VELAGAPUDI VR, NÚÑEZ V, FUENTES L, MONTANER D, et al. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 2011;60:797-809.

- OLATZ I, DANIEL L, IGNACIO S, JOAN CARLES D, MONTSERRAT V. Inflamación y obesidad (lipoinflamación). Nutr Hosp. 2015;31(6):2352-2358.

- LI J, YIN Q, WU H. Structural basis of signal transduction in the TNF receptor superfamily. Adv Immunol. 2013;119:135?53

- AYE ILMH, LAGER S, RAMIREZ VI, GACCIOLI F, DUDLEY DJ, JANSSON T. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol reprod. 2014;90(6):1-9.

- SABEN J, ZHONG Y, GOMEZ-ACEVEDO H, THAKALI KM, BORENGASSER SJ, ANDRES A. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Am J Physiol Endocrinol Metab. 2013;305:1-14.

- HOTAMISLIGIL GS, ERBAY E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008;8:923?34.

– CZECH MP. Insulin action and resistance in obesity and type 2 diabetes. Nat Med. 2017; 23(7):804-814

- HAMZA EH, DI VINCENZO A, VETTOR R. et al. Cardio-metabolic disorders in non-alcoholic fatty liver disease. Int J Mol Sci. 2019;20(9):2215.

- OBEN JA, MOURALIDARANI A, SAMUELSSON AM, MATTHEWS PJ, MORGAN ML, MCKEE C, et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol. 2010;52:913-20.

- PRUIS MG, LENDVAI A, BLOKS VW, et al. Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring. Acta Physiol. 2014;210(1):215-27.

- BESSONE F. Non-steroidal anti-inflammatory drugs: what is the actual risk of liver damage. World J Gastroenterol. 2010;16(45):5651-61.

- SINGH BK. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. Plos One. 2012;7(4).

Downloads

Published

2021-01-26

How to Cite

Melo, N. C. de O., Araújo, N. C. de M., Freire, A. R., Maia, M. B. de S., & Nascimento, E. do. (2021). The maternal western diet exacerbates the inflammatory response in the offspring, but does not alter the action of the non-steroidal anti-inflammatory drug/ Dieta ocidentalizada materna exacerba a resposta inflamatória na prole, mas não altera a eficácia da ação de droga anti-inflamatória não esteroidal. Brazilian Journal of Development, 7(1), 10084–10105. https://doi.org/10.34117/bjdv7n1-683

Issue

Section

Original Papers