Obtenção E Caracterização De Complexo De Inclusão De ?-Ciclodextrina E Eugenol / Preparation And Characterization Of ?-Cyclodextrin Inclusion Complex Of Eugenol

Authors

  • Camila Auad Beltrão de Freitas Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Raíssa Cristine Santos de Araújo
  • Simone Patrícia Aranha da Paz
  • José Rogério de Araújo Silva
  • Cláudio Nahum Alves
  • Jerônimo Lameira

DOI:

https://doi.org/10.34117/bjdv7n3-838

Keywords:

Eugenol, ?-ciclodextrina, Complexo de Inclusão.

Abstract

O eugenol é um fenilpropanóide presente em óleos essenciais de diversas plantas, cabendo destaque ao Cravo-da-Índia. Esta substância possui considerável importância farmacológica devido às suas atividades antioxidantes, porém, sua alta volatilização e instabilidade físico-química a fatores ambientais (luz, oxigênio e calor) têm dificultado seu uso tal qual nas formulações farmacêuticas. Neste contexto, buscou-se no presente trabalho produzir complexos de inclusão de eugenol em ?-ciclodextrina a fim de amenizar tais limitações. A complexação foi realizada por meio de coprecipitação e evaporação do solvente, em proporção molar de eugenol:?-ciclodextrina (1:1). Os complexos foram caracterizados por Difratometria de Raios-X (DRX); Espectroscopia de Infravermelho por Transformada de Fourier (FTIR). Os resultados revelaram que é possível caracterizar a interação hóspede/hospedeiro e, portanto, o êxito no processo de complexação, a partir de dados difratométricos (DRX) e espectrais (FTIR), o que torna o uso destas duas técnicas adequado para pesquisas no desenvolvimento de compostos com interesse biológico.

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Published

2021-03-31

How to Cite

de Freitas, C. A. B., de Araújo, R. C. S., da Paz, S. P. A., Silva, J. R. de A., Alves, C. N., & Lameira, J. (2021). Obtenção E Caracterização De Complexo De Inclusão De ?-Ciclodextrina E Eugenol / Preparation And Characterization Of ?-Cyclodextrin Inclusion Complex Of Eugenol. Brazilian Journal of Development, 7(3), 33056–33070. https://doi.org/10.34117/bjdv7n3-838

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Section

Original Papers