Analgesic Efficacy of Cordia Verbenacea-based Gel in the Reduction of Pain Associated with Use of Separator Elastics/ Eficácia Analgésica do Gel à base de Cordia Verbenacea na Redução de Dor Associada ao Uso de Elásticos Separadores

Itauana Vettorello, Daniele Michelin Paganotte, Adilson Sartorato, Vivian Fernandes Furletti de Góes, Andrea Aparecida de Aro, William Custodio, Cristina Maria Franzini


Introduction: In Orthodontics separator elastics are used to create space for inserting the bands. This causes pain. Phytotherapy has been promising as a therapy. Objective. This double blind randomized clinical trial evaluated the level of pain due to the use of elastic separator (SE) after intraoral topical administration of Cordia verbenacea gel (CV). Methods. 50 volunteers received the SE on the mesial and distal surfaces of the maxillary first molars. In a blinded manner, 0.5 g of the gel was used in one hemi-arch, and placebo in the other hemi-arch on the free gingival margin of the first molar, every 8 hours, for 3 days. Pain was measured on a visual analog scale (VAS), before insertion of the SE (t0), immediately after (t1) and every hour after the following applications. Sensory analysis of the was performed for effects of taste and burning. Wilcoxon (comparison between sides) and Friedman and Nemenyi tests were performed for comparisons between times (?=0.05). Results. The pain was lower on the side that received the phytotherapeutic gel, from the first application until before the removal of the elastic (p< 0.05).  As regards the burning sensation, the experimental side had higher scores and 20% of the subjects considered the CV gel had an unpleasant taste. It was concluded that the use of the intrabucal topic of CV has an analgesic potential for pain resulting from the insertion of SE.


Pain, Orthodontics, Therapeutic action, Cordea verbenacea.

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