Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica

Authors

  • Flávia Barbosa Pinto Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Cinthia Vidal Monteiro da Silva Couto
  • Anderson Barros Archanjo
  • Mayara Mota Oliveira
  • Joaquim Gasparini dos Santos
  • Otávio Pereira Oliveira
  • Pollyanna Ibrahim Silva
  • Jankerle Neves Boeloni
  • Louisiane de Carvalho Nunes
  • Adriana Madeira Álvares da Silva
  • Leonardo Oliveira Trivilin

DOI:

https://doi.org/10.34117/bjdv7n10-319

Keywords:

carcinogenesis, experimental model, liver injuries, renal injuries, biocompounds

Abstract

The objective was to report the injuries on liver and kidney promoted by experimental colorectal carcinogenesis induction in rats and evaluate the effect of supplementation with Euterpe edulis M. pulp products on resolution of this injuries. Colorectal carcinogenesis with 1,2-dimethylhydrazine was induced in young male rats, allocated into: C - induced to carcinogenesis; CJ - induced to carcinogenesis and supplemented with juçara fruit pulp; and CE - induced to carcinogenesis and supplemented with juçara fruit lyophilized extract. Nine animals were a negative control. Supplementation occurred three times a week, totaling 54 days of administration with 1 mg of cyanidin-3-glycoside per kilogram live weight. The hepatic and renal histopathological injuries were assessed at 10 and 23 weeks. In liver, at 10-week biliary hyperplasia was more evident in colorectal cancer induced groups compared to N group (p = 0.0230), as well as megalocytosis (p = 0.0269), and juçara fruit-based product do not promote cytoprotection. At 23-week biliary hyperplasia continued present, and liver necrosis was evident in C group and CJ group. Hepatic degeneration was greater in C group, and megalocytosis was evident in the cancer-induced groups, without cytoprotection by juçara fruit-based product. In kidney, at 23-week, renal congestion was more evident in CJ group, and tubular degeneration in C and CE groups. Important hepatic and renal injuries were observed in rats induced to colorectal cancer and the supplementation with juçara fruit-based product, in the dose used, did not interfere in the prevention and resolution of these injuries, mainly with the chronic use.

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2021-10-22

How to Cite

Pinto, F. B., Couto, C. V. M. da S., Archanjo, A. B., Oliveira, M. M., dos Santos, J. G., Oliveira, O. P., Silva, P. I., Boeloni, J. N., Nunes, L. de C., da Silva, A. M. Álvares, & Trivilin, L. O. (2021). Euterpe edulis pulp products and your effect on liver and kidney of in vivo model of colorectal cancer: Histopathological analysis / Produtos da polpa de Euterpe edulis e seus efeitos no fígado e nos rins em modelo in vivo de câncer colorretal: Análise histopatológica. Brazilian Journal of Development, 7(10), 99446–99464. https://doi.org/10.34117/bjdv7n10-319

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