Synthesis of 2',4,4'-trimethoxychalcon and in vitro cytotoxic study in human tumor cells / Síntese da 2',4,4'-trimetoxichalcona e estudo citotóxico in vitro em células tumorais humanas

Authors

  • Tamyrys Fernandes Vilar Bento Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Luiz André Araujo Silva
  • Flávio Valadares Pereira Borges
  • Bruno Hanrry Melo de Oliveira
  • Fernando Ferreira Leite
  • Sâmia Sousa Duarte
  • Marianna Vieira Sobral
  • Luis Cézar Rodrigues

DOI:

https://doi.org/10.34117/bjdv5n10-255

Keywords:

Chalcone, Organic Synthesis, Cytotoxicity, Aldol Condensation, HL-60.

Abstract

Chalcones are a class of natural compounds, aromatic ketones that forms central core for several important pharmacological activities reported such as anticarcinogenicity and antioxidation activities. Due to those important properties, the purpose of this work is the organic synthesis of 2’,4,4'-trimethoxychalcone and its cytotoxicity test against four human tumor cell lines: HL-60 (human promyelocytic leukemia), HCT-116 (human colorectal carcinoma), MCF-7 (human breast adenocarcinoma) and K562 (chronic myeloid leukemia) and also evaluated in normal cells L929 (murine fibroblast). The synthesis of  2', 4,4'-trimethoxychalcone was successful and in the viability cell assay (MTT assay), the HL-60 strain was found to have an inhibitory potential of 84.5% and an IC50 of approximately 20.84 µM.

 

 

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Published

2019-10-21

How to Cite

Bento, T. F. V., Silva, L. A. A., Borges, F. V. P., Oliveira, B. H. M. de, Leite, F. F., Duarte, S. S., Sobral, M. V., & Rodrigues, L. C. (2019). Synthesis of 2’,4,4’-trimethoxychalcon and in vitro cytotoxic study in human tumor cells / Síntese da 2’,4,4’-trimetoxichalcona e estudo citotóxico in vitro em células tumorais humanas. Brazilian Journal of Development, 5(10), 20779–20788. https://doi.org/10.34117/bjdv5n10-255

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Section

Original Papers