Moderate Exercise and Immune Response in Rats: A Model for Cancer Prevention / Exercício Moderado e Resposta Imune em Ratos: Um Modelo para a Prevenção do Câncer

Authors

  • Claudia Mirian de Godoy Marques Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Patricia Veronica Lawford
  • Jefferson Luiz Brum Marques
  • Thomas Cochrane

DOI:

https://doi.org/10.34117/bjdv8n1-367

Keywords:

Exercise, Wistar rats, Immune response, Cancer.

Abstract

Exercise is believed to cause changes in population and/or activity of immunocompetent cells. Study of this relationship is difficult in humans because of the multifactorial nature of human physiology and concomitant problems in controlling extraneous variables. We have investigated the effects of 4 weeks of moderate exercise training on percentage of NK cells and Lymphocyte activity in Wistar male rats under tightly controlled laboratory conditions. The animals were randomized into two groups: exercise and control. Exercised rats ran at a treadmill speed of 20 m/min (moderate exercise intensity), for 20 minutes, 6 days/week. Laboratory and handling conditions were matched, and food was controlled for both groups. Twenty-four hours after the exercise training program, lymphocyte response did not change significantly (p>0.05). Exercised rats demonstrated a significant increase in the percentage of circulating NK cell population (p<0.05). Exercise training demonstrated a significantly lower body weight for the exercised rats (p<0.05). With this simple model, this study supports the concept that regular moderate exercise leads to beneficial changes in the immunological response that may prevent cancer.

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Published

2022-01-20

How to Cite

Marques, C. M. de G., Lawford, P. V., Marques, J. L. B., & Cochrane, T. (2022). Moderate Exercise and Immune Response in Rats: A Model for Cancer Prevention / Exercício Moderado e Resposta Imune em Ratos: Um Modelo para a Prevenção do Câncer. Brazilian Journal of Development, 8(1), 5448–5466. https://doi.org/10.34117/bjdv8n1-367

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Original Papers