Suplementação em excesso com Ácido Fólico durante o pré-natal: revisão da literatura / Excessive supplementation with Folic Acid during prenatal: literature review

Ana Claudia Morandi Alessio, Luiz Eduardo Alessio Junior, Yorisley Lavina Hernandez, Camila Pinfildi

Abstract


A suplementação com ácido fólico para evitar defeitos no fechamento do tubo neural é recomendada como parte do cuidado pré-natal. As diretrizes recomendam administrar 400µg diários de AF, não podendo esta dose ultrapassar 1000µg diários. No entanto, não é incomum nos depararmos com casos em que a ingestão de AF supera as doses recomendadas, o que constitui uma realidade preocupante, uma vez que os efeitos decorrentes do uso crônico de doses elevadas desta vitamina ainda não são totalmente esclarecidos. Foi realizada uma análise da literatura dos últimos 10 anos, foram selecionados 09 artigos. Alguns dos malefícios que podem estar associados ao excesso de AF no pré-natal incluem aumento do risco de desenvolvimento de asma na infância, bem como infecções de via aérea superior e chiados; exacerbação de deficiência de B12; comprometimento do crescimento fetal; influência no desenvolvimento do cérebro (autismo); reações alérgicas (eczema); promoção do câncer (tumor de mama e adenoma colorretal); aumento resistência à insulina nas crianças; e risco de diabetes gestacional. Esse estudo alerta sobre a importância da adequação do SUS em fornecer comprimidos de AF na dose adequada para gestante, uma vez que os comprimidos ofertados pelo SUS são na dose de 5mg, o que é aproximadamente 10 vezes maior que o recomendado.

 


Keywords


ácido fólico, suplementação dietética, pré-natal.

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DOI: https://doi.org/10.34117/bjdv8n6-200