Câncer de Mama no Homem: uma Revisão Narrativa/ Breast Cancer in Man: a Narrative Review

Authors

  • Luiz Augusto Debona
  • Flávio Lúcio Vasconcelos
  • Felinto Cardoso Pereira
  • Harry Francisco Monteiro de Lima
  • Letícia Rocha Santos Maciel
  • David da Silva Nunes

DOI:

https://doi.org/10.34119/bjhrv4n6-024

Keywords:

câncer masculino, câncer de mama, neoplasia da mama, câncer de mama no homem, câncer no homem, homem, nódulo, localmente avançado, carcinoma ductal invasivo, luminal B, hormonioterapia, tamoxifeno, hormonioterapia neoadjuvante.

Abstract

O câncer de mama masculino é uma patologia rara e com poucas publicações disponíveis. Apresenta suas próprias particularidades, porém algumas características são comuns ao câncer de mama feminino. Assim, muito do que se sabe atualmente sobre diagnóstico e tratamento é extrapolado a partir do conhecimento sobre o acometimento no sexo feminino. O quadro clínico típico é marcado pelo surgimento de uma nodulação indolor, em geral em região retro areolar. A investigação da nodulação ocorre através da mamografia e da ultrassonografia mamária. O tratamento baseia-se na intervenção cirúrgica através da mastectomia e na hormonioterapia adjuvante. Esta revisão traz um resumo das principais evidências científicas acerca dos temas de: epidemiologia, fatores de risco, quadro clínico, diagnóstico, tratamento e prognóstico do câncer de mama masculino.

References

AMERICAN CANCER SOCIETY (ACS). Cancer Statistics Center. Disponível em:<https://cancerstatisticscenter.cancer.org/?_ga=2.153853944.1331183633.1586203391-375117975.1586203391#!/cancer-site/Breast>. Acesso em: 15 maio de 2020.

ANDERSON, William F. et al. Is male breast cancer similar or different than female breast cancer?. Breast cancer research and treatment, v. 83, n. 1, p. 77-86, 2004.

ANDERSON, William F. et al. Male breast cancer: a population-based comparison with female breast cancer. Journal of Clinical Oncology, v. 28, n. 2, p. 232, 2010.

ANDERSON, William F.; DEVESA, Susan S. In situ male breast carcinoma in the Surveillance, Epidemiology, and End Results database of the National Cancer Institute. Cancer, v. 104, n. 8, p. 1733-1741, 2005.

AUVINEN, Anssi; CURTIS, Rochelle E.; RON, Elaine. Risk of subsequent cancer following breast cancer in men. Journal of the National Cancer Institute, v. 94, n. 17, p. 1330-1332, 2002.

BAGLEY, Caroline S. et al. Adjuvant chemotherapy in males with cancer of the breast. American journal of clinical oncology, v. 10, n. 1, p. 55-60, 1987.

BASHAM, Victoria M. et al. BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. Breast Cancer Research, v. 4, n. 1, p. R2, 2001.

BLOOM, Kenneth J. et al. Status of HER-2 in male and female breast carcinoma. The American journal of surgery, v. 182, n. 4, p. 389-392, 2001.

BORGEN, PATRICK I. et al. Current management of male breast cancer. A review of 104 cases. Annals of surgery, v. 215, n. 5, p. 451, 1992.

BOUGHEY, Judy C. et al. Comparative analysis of sentinel lymph node operation in male and female breast cancer patients. Journal of the American College of Surgeons, v. 203, n. 4, p. 475-480, 2006.

BRINTON, Louise A. Breast cancer risk among patients with Klinefelter syndrome. Acta paediatrica, v. 100, n. 6, p. 814-818, 2011..

BURGA, Ana M. et al. Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases. Virchows Archiv, v. 449, n. 5, p. 507-512, 2006.

CARDOSO, Fatima et al. Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program. Annals of oncology, v. 29, n. 2, p. 405-417, 2018.

CARRASCO, Rafaela Muñoz et al. Mammography and ultrasound in the evaluation of male breast disease. European radiology, v. 20, n. 12, p. 2797-2805, 2010.

CHAGPAR, Anees et al. Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. Archives of surgery, v. 139, n. 6, p. 614-620, 2004.

CHEN, Xuesong et al. Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer. Journal of Experimental & Clinical Cancer Research, v. 33, n. 1, p. 28, 2014.

COHEN, P. G. The hypogonadal–obesity cycle: role of aromatase in modulating the testosterone–estradiol shunt–a major factor in the genesis of morbid obesity. Medical hypotheses, v. 52, n. 1, p. 49-51, 1999.

CONTRACTOR, Kaiyumars B. et al. Male breast cancer: is the scenario changing. World journal of surgical oncology, v. 6, n. 1, p. 58, 2008.

CORTAZAR, Patricia et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. The Lancet, v. 384, n. 9938, p. 164-172, 2014.

CUTULI, B. et al. Ductal carcinoma in situ of the male breast. Analysis of 31 cases. European Journal of Cancer, v. 33, n. 1, p. 35-38, 1997.

CUTULI, B. et al. Male breast cancer: results of the treatments and prognostic factors in 397 cases. European Journal of Cancer, v. 31, n. 12, p. 1960-1964, 1995.

DEBONA, Luiz Augusto et al. Hormonioterapia em Câncer de Mama Masculino Localmente Avançado: Relato de Caso. Brazilian Journal of Development, v. 6, n. 12, p. 98902-98918, 2020.

DI LAURO, Luigi et al. Efficacy of chemotherapy in metastatic male breast cancer patients: a retrospective study. Journal of Experimental & Clinical Cancer Research, v. 34, n. 1, p. 26, 2015.

DING, Yuan Chun et al. Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States. Breast cancer research and treatment, v. 126, n. 3, p. 771-778, 2011.

DONG, Chuanhui; HEMMINKI, Kari. Second primary breast cancer in men. Breast cancer research and treatment, v. 66, n. 2, p. 171, 2001.

DOYLE, S.; STEEL, J.; PORTER, G. Imaging male breast cancer. Clinical radiology, v. 66, n. 11, p. 1079-1085, 2011.

ESTIMATIVA, I. N. C. A. et al. incidência de câncer no Brasil. Rio de Janeiro, 2019.

EVANS, Gregory FF et al. The diagnostic accuracy of mammography in the evaluation of male breast disease. The American journal of surgery, v. 181, n. 2, p. 96-100, 2001.

EWERTZ, Marianne et al. Risk Factors for male breast cancer? A case-control study from Scandinavia. Acta Oncologica, v. 40, n. 4, p. 467-471, 2001.

FACKENTHAL, James D. et al. Male breast cancer in Cowden syndrome patients with germlinePTEN mutations. Journal of medical genetics, v. 38, n. 3, p. 159-164, 2001.

FENTIMAN, Ian S.; FOURQUET, Alain; HORTOBAGYI, Gabriel N. Male breast cancer. The Lancet, v. 367, n. 9510, p. 595-604, 2006..

FINN, Richard S. et al. Palbociclib and letrozole in advanced breast cancer. New England Journal of Medicine, v. 375, n. 20, p. 1925-1936, 2016.

FRIEDMAN, Lori S. et al. Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. American journal of human genetics, v. 60, n. 2, p. 313, 1997.

GIANNI, Luca et al. 5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial. The lancet oncology, v. 17, n. 6, p. 791-800, 2016.

GIORDANO, S. H.; BUZDAR, A. U.; HORTOBAGYI, G. N. Male breast cancer. Ann Intern Med, v. 137, n. 8, p. 678-687, 2002.

GIORDANO, Sharon H. Breast cancer in men. New England Journal of Medicine, v. 378, n. 24, p. 2311-2320, 2018.

GIORDANO, Sharon H. et al. Adjuvant systemic therapy for male breast carcinoma. Cancer: Interdisciplinary International Journal of the American Cancer Society, v. 104, n. 11, p. 2359-2364, 2005..

GIORDANO, Sharon H. et al. Breast carcinoma in men: a population‐based study. Cancer: Interdisciplinary International Journal of the American Cancer Society, v. 101, n. 1, p. 51-57, 2004.

GOETZ, Matthew P. et al. MONARCH 3: abemaciclib as initial therapy for advanced breast cancer. Journal of Clinical Oncology, v. 35, n. 32, p. 3638-3646, 2017.

GOSS, Paul E. et al. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955–1996. Cancer: Interdisciplinary International Journal of the American Cancer Society, v. 85, n. 3, p. 629-639, 1999.

GOUGH, D. B. et al. A 50-year experience of male breast cancer: is outcome changing?. Surgical oncology, v. 2, n. 6, p. 325-333, 1993.

GRADISHAR, William J. et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). Journal of the National Comprehensive Cancer Network, v. 18, n. 4, 2020.

GREIF, Jon M. et al. Gender differences in breast cancer: analysis of 13,000 breast cancers in men from the National Cancer Data Base. Annals of surgical oncology, v. 19, n. 10, p. 3199-3204, 2012.

GUINEE, Vincent F. et al. The prognosis of breast cancer in males a report of 335 cases. Cancer, v. 71, n. 1, p. 154-161, 1993.

GÜNHAN-BILGEN, Işıl et al. Male breast disease: clinical, mammographic, and ultrasonographic features. European journal of radiology, v. 43, n. 3, p. 246-255, 2002.

HANAVADI, S.; MONYPENNY, I. J.; MANSEL, R. E. Is mammography overused in male patients?. The Breast, v. 15, n. 1, p. 123-126, 2006..

HANSEN, Johnni. Elevated risk for male breast cancer after occupational exposure to gasoline and vehicular combustion products. American journal of industrial medicine, v. 37, n. 4, p. 349-352, 2000.

HARBECK, N. et al. Breast Cancer. Nat. Rev. Dis. Primers 5, 66, 2019.

HARLAN, Linda C. et al. Breast cancer in men in the United States: a population‐based study of diagnosis, treatment, and survival. Cancer, v. 116, n. 15, p. 3558-3568, 2010.

HARNDEN, D. G.; MACLEAN, N.; LANGLANDS, A. O. Carcinoma of the breast and Klinefelter's syndrome. Journal of medical genetics, v. 8, n. 4, p. 460, 1971.

HEMMINKI, Kari et al. Second primary malignancies in patients with male breast cancer. British journal of cancer, v. 92, n. 7, p. 1288-1292, 2005.

HICKEY, T. E. et al. Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?. Molecular endocrinology, v. 26, n. 8, p. 1252-1267, 2012.

HINES, Stephanie L. et al. The role of mammography in male patients with breast symptoms. In: Mayo Clinic Proceedings. Elsevier, 2007. p. 297-300.

HORTOBAGYI, Gabriel N. et al. Ribociclib as first-line therapy for HR-positive, advanced breast cancer. New England Journal of Medicine, v. 375, n. 18, p. 1738-1748, 2016.

HSING, Ann W. et al. Risk factors for male breast cancer (United States). Cancer causes & control, v. 9, n. 3, p. 269-275, 1998.

JAIYESIMI, Ishmael A. et al. Carcinoma of the male breast. Annals of internal medicine, v. 117, n. 9, p. 771-777, 1992.

JAMES, Ted A. et al. Troubleshooting sentinel lymph node biopsy in breast cancer surgery. Annals of surgical oncology, v. 23, n. 11, p. 3459-3466, 2016.

KRAG, David N. et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. The lancet oncology, v. 8, n. 10, p. 881-888, 2007.

LATTIN JR, Grant E. et al. From the radiologic pathology archives: diseases of the male breast: radiologic-pathologic correlation. Radiographics, v. 33, n. 2, p. 461-489, 2013.

LENFANT‐PEJOVIC, Marie‐Hélène et al. Risk factors for male breast cancer: A Franco‐Swiss case‐control study. International journal of cancer, v. 45, n. 4, p. 661-665, 1990.

LIEDE, Alexander; KARLAN, Beth Y.; NAROD, Steven A. Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. Journal of Clinical Oncology, v. 22, n. 4, p. 735-742, 2004.

LYMAN, G. H. et al. American Society of Clinical Oncology. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol, v. 23, n. 30, p. 7703-7720, 2005.

MACDONALD, G. et al. A comparative analysis of radiotherapy use and patient outcome in males and females with breast cancer. Annals of oncology, v. 16, n. 9, p. 1442-1448, 2005.

MARTIN II, Robert CG et al. Practical guidelines for optimal gamma probe detection of sentinel lymph nodes in breast cancer: results of a multi-institutional study. Surgery, v. 128, n. 2, p. 139-144, 2000.

MCGALE, P. et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. 2014.

MEDRAS, Marek et al. Breast cancer and long-term hormonal treatment of male hypogonadism. Breast cancer research and treatment, v. 96, n. 3, p. 263-265, 2006.

MICHAELS, B. M.; NUNN, C. R.; ROSES, D. F. Lobular carcinoma of the male breast. Surgery, v. 115, n. 3, p. 402-405, 1994.

NIELL, Bethany L. et al. ACR Appropriateness Criteria® evaluation of the symptomatic male breast. Journal of the American College of Radiology, v. 15, n. 11, p. S313-S320, 2018.

PISANO, Etta D. et al. Fine-needle aspiration biopsy of nonpalpable breast lesions in a multicenter clinical trial: results from the radiologic diagnostic oncology group V. Radiology, v. 219, n. 3, p. 785-792, 2001.

PRICE, W. H. et al. Causes of death in X chromatin positive males (Klinefelter's syndrome). Journal of Epidemiology & Community Health, v. 39, n. 4, p. 330-336, 1985.

PUGLISI, F. et al. Baseline staging tests after a new diagnosis of breast cancer: further evidence of their limited indications. Annals of Oncology, v. 16, n. 2, p. 263-266, 2005.

REINISCH, M. et al. Abstract PD7-10: Male-GBG54: A prospective, randomised multi-centre phase II study evaluating endocrine treatment with either tamoxifen+/-gonadotropin releasing hormone analogue (GnRHa) or an aromatase inhibitor+ GnRHa in male breast cancer patients. 2018.

RIBEIRO, G. G. et al. A review of the management of the male breast carcinoma based on an analysis of 420 treated cases. The Breast, v. 5, n. 3, p. 141-146, 1996.

RON, Elaine et al. Male breast cancer incidence among atomic bomb survivors. Journal of the National Cancer Institute, v. 97, n. 8, p. 603-605, 2005.

ROTH, Mara Y.; AMORY, John K.; PAGE, Stephanie T. Treatment of male infertility secondary to morbid obesity. Nature clinical practice Endocrinology & metabolism, v. 4, n. 7, p. 415-419, 2008.

RUDDY, Kathryn J.; WINER, E. P. Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship. Annals of oncology, v. 24, n. 6, p. 1434-1443, 2013..

SASCO, Annie J.; LOWENFELS, Albert B.; JONG, Pieternel Pasker‐De. epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors. International journal of cancer, v. 53, n. 4, p. 538-549, 1993.

SCHWARTZ, Gordon F. et al. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19–22, 2001, Philadelphia, Pennsylvania. Cancer, v. 94, n. 10, p. 2542-2551, 2002.

SIEGEL, Rebecca L.; MILLER, Kimberly D.; JEMAL, Ahmedin. Cancer statistics, 2019. CA: a cancer journal for clinicians, v. 69, n. 1, p. 7-34, 2019.

SILVESTRI, Valentina et al. PALB2 mutations in male breast cancer: a population-based study in Central Italy. Breast cancer research and treatment, v. 122, n. 1, p. 299-301, 2010.

STRUEWING, Jeffery P. et al. Founder BRCA1/2 mutations among male patients with breast cancer in Israel. The American Journal of Human Genetics, v. 65, n. 6, p. 1800-1802, 1999.

SYMMERS, W. St. Carcinoma of breast in trans-sexual individuals after surgical and hormonal interference with the primary and secondary sex characteristics. British Medical Journal, v. 2, n. 5597, p. 83, 1968.

TAI, Yu Chuan et al. Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute, v. 99, n. 23, p. 1811-1814, 2007.

THIRUCHELVAM, Paul et al. Gynaecomastia. BMJ, v. 354, p. i4833, 2016.

THOMAS, David B. et al. Breast cancer in men: risk factors with hormonal implications. American Journal of Epidemiology, v. 135, n. 7, p. 734-748, 1992.

VAN GEEL, A. N. et al. A retrospective study of male breast cancer in Holland. British journal of surgery, v. 72, n. 9, p. 724-727, 1985.

VIEIRA, Sabas Carlos et al. Câncer de mama: Consenso da Sociedade Brasileira de Mastologia-Regional Piauí–2017. Teresina: EDUFPI, 2017.

WANG, Christina et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes care, v. 34, n. 7, p. 1669-1675, 2011.

WANG-RODRIGUEZ, Jessica et al. Male breast carcinoma: correlation of ER, PR, Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 cases. Modern pathology, v. 15, n. 8, p. 853-861, 2002.

WHITE, Jonathan et al. Male breast carcinoma: increased awareness needed. Breast Cancer Research, v. 13, n. 5, p. 219, 2011.

WILLSHER, Peter C. et al. A comparison outcome of male breast cancer with female breast cancer. The American journal of surgery, v. 173, n. 3, p. 185-188, 1997.

YALAZA, Metin; İNAN, Aydın; BOZER, Mikdat. Male breast cancer. The journal of breast health, v. 12, n. 1, p. 1, 2016.

YEN, Peggy PW et al. Benign and malignant male breast diseases: radiologic and pathologic correlation. Canadian Association of Radiologists' Journal, v. 66, n. 3, p. 198-207, 2015.

YILDIRIM, Emin; BERBEROĞLU, Uğur. Male breast cancer: a 22-year experience. European Journal of Surgical Oncology (EJSO), v. 24, n. 6, p. 548-552, 1998.

YONEY, A.; KUCUK, A.; UNSAL, M. Male breast cancer: a retrospective analysis. Cancer/Radiothérapie, v. 13, n. 2, p. 103-107, 2009.

Published

2021-11-17

How to Cite

DEBONA, L. A.; VASCONCELOS, F. L.; PEREIRA, F. C.; LIMA, H. F. M. de; MACIEL, L. R. S.; NUNES, D. da S. Câncer de Mama no Homem: uma Revisão Narrativa/ Breast Cancer in Man: a Narrative Review. Brazilian Journal of Health Review, [S. l.], v. 4, n. 6, p. 23921–23942, 2021. DOI: 10.34119/bjhrv4n6-024. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/39656. Acesso em: 29 mar. 2024.

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Section

Original Papers