Eficácia dos inibidores da dipeptidil peptidase 4 (DPP-4) para o tratamento da diabetes mellitus 2 / Efficacy of dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus

Authors

  • Karinne Nancy Sena Rocha
  • Bruna Magalhães Pereira
  • Iago Ladeia Costa
  • Giullia Gonçalves Fabri
  • Camilla Negrão Wilhans
  • Letícia Fagundes Lemos
  • Marlon Ramos Rosado Machado
  • Marcela Sales De Lucca Rodrigues

DOI:

https://doi.org/10.34119/bjhrv5n1-026

Keywords:

Diabetes Mellitus, Inibidores da Dipeptidil Peptidase IV, Eficácia.

Abstract

As terapias à base de peptídeo semelhante ao glucagon 1, como os inibidores da dipeptidil peptidase 4, agonistas do receptor de GLP-1, afetam o controle da glicose por meio de mecanismos, incluindo aumento da secreção de insulina dependente de glicose, lentidão gástrica esvaziamento e redução do glucagon pós-prandial e da ingestão de alimentos. Os inibidores da DPP-4 podem ser considerados como monoterapia em pacientes com diabetes tipo 2 que são intolerantes ou têm contraindicações à metformina ou outros agentes redutores da glicose. Os inibidores da DPP-4 podem ser considerados como terapia medicamentosa adicional para pacientes que são inadequadamente controlados com metformina , uma tiazolidinediona, inibidor do co-transportador 2 de sódio-glicose ou uma sulfonilureia. Os inibidores DPP-4 parecem ter eficácia glicêmica semelhante, eles resultam em uma melhora modesta na hemoglobina glicada. 

References

Koliaki C, Doupis J. Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus. Diabetes Ther 2011; 2:101.

Demuth HU, McIntosh CH, Pederson RA. Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors. Biochim Biophys Acta 2005; 1751:33.

Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273:E981.

Rosenstock J, Kahn SE, Johansen OE, et al. Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial. JAMA 2019; 322:1155.

Salvo F, Moore N, Arnaud M, et al. Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis. BMJ 2016; 353:i2231.

Bergman AJ, Cote J, Yi B, et al. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care 2007; 30:1862.

Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 2008; 10:376.

Gomis R, Espadero RM, Jones R, et al. Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 2011; 13:653.

Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368:1696.

Richter B, Bandeira-Echtler E, Bergerhoff K, Lerch CL. Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008; :CD006739.

Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013; 369:1317.

Zannad F, Cannon CP, Cushman WC, et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 2015; 385:2067.

McGuire DK, Alexander JH, Johansen OE, et al. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA. Circulation 2019; 139:351.

Toh S, Hampp C, Reichman ME, et al. Risk for Hospitalized Heart Failure Among New Users of Saxagliptin, Sitagliptin, and Other Antihyperglycemic Drugs: A Retrospective Cohort Study. Ann Intern Med 2016; 164:705.

Liu J, Li L, Deng K, et al. Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis. BMJ 2017; 357:j2499.

McGill JB, Sloan L, Newman J, et al. Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study. Diabetes Care 2013; 36:237.

Nauck MA, Meininger G, Sheng D, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2007; 9:194.

Bosi E, Camisasca RP, Collober C, et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007; 30:890.

Owens DR, Swallow R, Dugi KA, Woerle HJ. Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med 2011; 28:1352.

Kutoh E, Ukai Y. Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial. Endocrine 2012; 41:435.

Abrahami D, Douros A, Yin H, et al. Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study. BMJ 2018; 360:k872.

Published

2022-01-11

How to Cite

ROCHA, K. N. S.; PEREIRA, B. M.; COSTA, I. L.; FABRI, G. G.; WILHANS, C. N.; LEMOS, L. F.; MACHADO, M. R. R.; RODRIGUES, M. S. D. L. Eficácia dos inibidores da dipeptidil peptidase 4 (DPP-4) para o tratamento da diabetes mellitus 2 / Efficacy of dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus. Brazilian Journal of Health Review, [S. l.], v. 5, n. 1, p. 286–303, 2022. DOI: 10.34119/bjhrv5n1-026. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/42489. Acesso em: 28 mar. 2024.

Issue

Section

Original Papers