A ingestão de proteína animal ou vegetal gera diferença na resposta anabólica no processo de hipertrofia muscular? / Does the ingestion of animal or vegetable protein generate a difference in the anabolic response in the process of muscle hypertrophy?

Authors

  • Mayra Natasha Santana da Silva
  • Tatiana dos Santos Dias
  • Nayara Sousa Castro

DOI:

https://doi.org/10.34119/bjhrv5n4-054

Keywords:

proteína vegetal, proteína animal, síntese de proteína muscular, massa muscular, exercício.

Abstract

Introdução: A proteína tem importante papel na hipertrofia, pois auxilia como substrato para síntese muscular e energia para a realização da contração muscular, sendo importantes componentes na base dos alimentos. Na hipertrofia são necessários os aminoácidos essenciais. A oferta de nutrientes antes, durante e pós exercício físico, é um agente primordial na resposta de adaptações musculares ao treinamento. Objetivo: Apontar os mecanismos no processo de hipertrofia muscular, mostrar através de estudos a diferença na resposta anabólica diante da suplementação de proteína de origem animal e vegetal. Materiais e métodos: Foram incluídos no estudo somente ensaios clínicos randomizados, meta-análises e revisões sistemáticas realizados em humanos, publicados nos últimos 10 anos. Conclusão: Os resultados apontam para maior síntese naqueles que utilizam a suplementação a partir da proteína de origem animal.

References

- GONZALEZ, Adam M.; HOFFMAN, Jay R.; JAJTNER, Adam R. et al. Protein supplementation does not alter intramuscular anabolic signaling or endocrine response after resistance exercise in trained men. Nutrition Research v. 35, P. 990- 1000, 2015.

- ÁLVAREZ-GARCÍA, Ó., GARCÍA-LÓPEZ, E., LOREDO, V. et al. Growth hormone improves growth retardation induced by rapamycin without blocking its antiproliferative and antiangiogenic effects on rat growth plate. PloS one, 7(4), e34788, 2012. https://doi.org/10.1371/journal.pone.0034788

- ANTHONY, J. C., ANTHONY, T. G., KIMBALL, S. R., & JEFFERSON, L. S. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. The Journal of nutrition, 131(3), 856S–860S, 2001. https://doi.org/10.1093/jn/131.3.856S

- BERRAZAGA, I., MICARD, V., GUEUGNEAU, M., & WALRAND, S. The Role of the Anabolic Properties of Plant- versus Animal-Based Protein Sources in Supporting Muscle Mass Maintenance: A Critical Review. Nutrients, 11(8), 1825, 2019. https://doi.org/10.3390/nu11081825

- BIKLE, D. D., TAHIMIC, C., CHANG, W., WANG, Y., PHILIPPOU, A., & BARTON, E. R. Role of IGF-I signaling in muscle bone interactions. Bone, 80, 79–88. 2015. https://doi.org/10.1016/j.bone.2015.04.036

- BOIRIE, Y., DANGIN, M., GACHON, P., VASSON, M. P., MAUBOIS, J. L., & BEAUFRÈRE, B. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proceedings of the National Academy of Sciences of the United States of America, 94(26), 14930–14935. 1997. https://doi.org/10.1073/pnas.94.26.14930

- BOSCO, C.; COLLI, R.; BONOMI, R.; VON DUVILLARD, S.P.; VIRU, A. Monitoringstrength training: neuromuscular and hormonal profile. Medicine and Science in Sports and Exercise. Vol.32, n1, pp: 13-28, 2000.

- BYE, J. W., COWIESON, N. P., COWIESON, A. J., SELLE, P. H., & FALCONER, R. J. Dual effects of sodium phytate on the structural stability and solubility of proteins. Journal of agricultural and food chemistry, 61(2), 290–295. 2013. https://doi.org/10.1021/jf303926v

- CREWTHER, B, KEOGH, J, CRONIN, J e COOK, C. Possible stimuli for strength and power adaptation: Acute hormonal responses. Sport Med 36: 215-238, 2006.

- DANGIN, M., BOIRIE, Y., GARCIA-RODENAS, C., GACHON, P., FAUQUANT, J., CALLIER, P., BALLÈVRE, O., & BEAUFRÈRE, B. The digestion rate of protein is an independent regulating factor of postprandial protein retention. American journal of physiology. Endocrinology and metabolism, 280(2), E340–E348. 2001. https://doi.org/10.1152/ajpendo.2001.280.2.E340

- DANGIN, M., BOIRIE, Y., GUILLET, C., & BEAUFRÈRE, B. Influence of the protein digestion rate on protein turnover in young and elderly subjects. The Journal of nutrition, 132(10), 3228S–33S. 2002. https://doi.org/10.1093/jn/131.10.3228S

- DANGIN, M., GUILLET, C., GARCIA-RODENAS, C., GACHON, P. et al. The rate of protein digestion affects protein gain differently during aging in humans. The Journal of physiology, 549(Pt 2), 635–644. 2003. https://doi.org/10.1113/jphysiol.2002.036897

- DEVOL, DL, ROTWEIN, P, SADOW, JL, NOVAKOFSKI, J, E BECHTEL, PJ. Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am J Physiol 259: E89-E95, 1990.

- FAO. Report of a sub-committee of the 2011 FAO Consultation on “Protein Quality Evaluation in Human Nutrition”: the assessment of amino acid digestibility in foods for humans and including a collation of published ileal amino acid digestibility data for human foods. Rome (Italy): FAO; 2012 USDA, Agricultural Research Service. National Nutrient Database for Standard Reference, release 26. Washington (DC): USDA; 2013. Available from: http://www.ars.usda.gov/ba/bhnrc/ndl.

- FRIEDMAN, M., & BRANDON, D. L. Nutritional and health benefits of soy proteins. Journal of agricultural and food chemistry, 49(3), 1069–1086. 2001. https://doi.org/10.1021/jf0009246

- GILANI, G. S., COCKELL, K. A., & SEPEHR, E. Effects of antinutritional factors on protein digestibility and amino acid availability in foods. Journal of AOAC International, 88(3), 967–987, 2005.

- GUERRA, I.; ALVES, L. A.; BIESEK, S. Estratégias de nutrição e suplementação no esporte. 2. ed. rev. e ampl. Barueri: Manole, 2010.

- HAKKINEN, K, PAKARINEN, A, KRAEMER, WJ, NEWTON, RU, AND ALEN, M. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol. Ser A, Biol Sci Med Sci 55: B95–B105, 2000.

- HAMEED, M, LANGE, KH, ANDERSEN, JL, SCHJERLING, P, KJAER, M, HARRIDGE, SD e GOLDSPINK, G. The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. J Physiol 555: 231-240, 2004.

- HAWKE, T. J., e GARRY, D. J. Myogenic satellite cells: physiology to molecular biology. Journal of applied physiology (Bethesda, Md.: 1985), 91(2), 534–551. 2001. https://doi.org/10.1152/jappl.2001.91.2.534

- HEVIA-LARRAÍN, V., GUALANO, B., LONGOBARDI, I. et al. High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores. Sports Med 51, 1317–1330. 2021. https://doi.org/10.1007/s40279-021-01434-9

- HILL, M., & GOLDSPINK, G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. The Journal of physiology, 549(Pt 2), 409–418. 2003. https://doi.org/10.1113/jphysiol.2002.035832

- HIRSCHBRUCH, Márcia Daskal; CARVALHO, Juliana Ribeiro. Nutrição esportiva: uma visão prática. São Paulo: Manole, 2002.

- JANSMAN, A. J., ENTING, H., VERSTEGEN, M. W., & HUISMAN, J. Effect of condensed tannins in hulls of faba beans (Vicia faba L.) on the activities of trypsin (EC 2.4.21.4) and chymotrypsin (EC 2.4.21.1) in digesta collected from the small intestine of pigs. The British journal of nutrition, 71(4), 627–641. 1994. https://doi.org/10.1079/bjn19940168

- JOY, JM, LOWERY, RP, WILSON, JM et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J 12, 86. 2013. Disponível em: https://doi.org/10.1186/1475-2891-12-86

- KELLEY, D. E., HE, J., MENSHIKOVA, E. V., & RITOV, V. B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes, 51(10), 2944–2950. 2002. https://doi.org/10.2337/diabetes.51.10.2944

- KERKSICK, C.M.; JAGIM, A.; HAGELE, A.; JÄGER, R. Plant Proteins and Exercise: What Role Can Plant Proteins Have in Promoting Adaptations to Exercise? Nutrients, 13, 1962. 2021. https://doi.org/10.3390/nu13061962

- KVORNING, T., ANDERSEN, M., BRIXEN, K., & MADSEN, K. Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study. American journal of physiology. Endocrinology and metabolism, 291(6), E1325–E1332. 2006. https://doi.org/10.1152/ajpendo.00143.2006

- LANGER, Henning BA; CARLSOHN, Anja PhD. Effects of Different Dietary Proteins and Amino Acids on Skeletal Muscle Hypertrophy in Young Adults After Resistance Exercise, Strength and Conditioning Journal: Volume 36 - Issue 3 - p 33-42. 2014. https://doi.org/10.1519/SSC.0000000000000057

- LIM, M.T.; PAN, B.J.; TOH, D.W.K.; SUTANTO, C.N.; KIM, J.E. Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 13, 661. 2021. https://doi.org/10.3390/nu13020661

- LYNCH, H.M.; BUMAN, M.P.; DICKINSON, J.M.; RANSDELL, L.B.; JOHNSTON, C.S.; WHARTON, C.M. No Significant Differences in Muscle Growth and Strength Development When Consuming Soy and Whey Protein Supplements Matched for Leucine Following a 12 Week Resistance Training Program in Men and Women: A Randomized Trial. Int. J. Environ. Res. Public Health, 17, 3871. 2020. https://doi.org/10.3390/ijerph17113871

- MELONI, V.H.M. O papel da hiperplasia na hipertrofia do músculo esquelético. Revista Brasileira de Cineantropometria e Desempenho Humano, v. 7, n. 1, 2005.

- MOBLEY, C Brooks et al. “Effects of Whey, Soy or Leucine Supplementation with 12 Weeks of Resistance Training on Strength, Body Composition, and Skeletal Muscle and Adipose Tissue Histological Attributes in College-Aged Males.” Nutrients vol. 9,9 972. 4 Sep. 2017, Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622732/

- MOORE, D. R., & SOETERS, P. B. The Biological Value of Protein. Nestle Nutrition Institute workshop series, vol. 82, p. 39–51. 2015. https://doi.org/10.1159/000382000

-MORTON, R.W.; MURPHY, K. T.; MCKELLAR, S. R., et al A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults British Journal of Sports Medicine;52:376-384. 2018.

- MUSARÒ, A., MCCULLAGH, K. J., NAYA, F. J., OLSON, E. N., & ROSENTHAL, N. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature, 400(6744), 581–585. 1999. https://doi.org/10.1038/23060

- OJASTO, T., & HÄKKINEN, K. Effects of different accentuated eccentric loads on acute neuromuscular, growth hormone, and blood lactate responses during a hypertrophic protocol. Journal of strength and conditioning research, 23(3), 946–953. 2009. https://doi.org/10.1519/JSC.0b013e3181a2b22f

- OLIVEIRA. J.E.D. de & VANNUCCHI, H. The protein requirement of Brazilian rural works studies with a rice and a bean a diet. In: RAND, W.M. Protein energy requirements of developing countries: results of international research. Tokio, United University, p. 98-114, 1983.

- PEDERSEN, B. K. Muscle as a secretory organ. Comprehensive Physiology, 3(3), 1337–1362. 2013. https://doi.org/10.1002/cphy.c120033

- REIDY, P. T., WALKER, D. K., DICKINSON, J. M., GUNDERMANN, D. M., DRUMMOND, M. J., et al. Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle. Journal of applied physiology (Bethesda, Md: (1985), 116(11), 1353–1364. 2014. https://doi.org/10.1152/japplphysiol.01093.2013

- Report of an FAO Experte consultation. Dietary protein quality evaluation in human nutrition. ISSN 0254-4725 FAO and food nutrition paper 92. 31 March – 2 April, 2011.

- ROSENBLATT, JD, YONG, D e PARRY, DJ. Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Mus Nerve 17: 608-613,1994.

- SANTOS, J.E., HOWE, J.M., DUARTE, F.A.M., OLIVEIRA, J.E.D. de. Relationship between the nutritional efficacy of a rice and bean diet and energy intake in pre-school childen. Am. J. Clin. Nutr., 32:1.541-4,1979.

- SARWAR, G.The protein digestibility-corrected amino acid score method overestimates quality of proteins containing antinutritional factors and of poorly digestible proteins supplemented with limiting amino acids in rats. The Journal of nutrition, 127(5), 758–764. 1997. https://doi.org/10.1093/jn/127.5.758

- SINHA-HIKIM, I., CORNFORD, M., GAYTAN, H., LEE, M. L., & BHASIN, S. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. The Journal of clinical endocrinology and metabolism, 91(8), 3024–3033. 2006. https://doi.org/10.1210/jc.2006-0357

- SURYAWAN, A., ORELLANA, R. A., FIOROTTO, M. L., & DAVIS, T. A. Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs. Journal of animal science, 89(7), 2004–2016. 2011. https://doi.org/10.2527/jas.2010-3400

- TANG, J. E., MOORE, D. R., KUJBIDA, G. W., TARNOPOLSKY, M. A., & PHILLIPS, S. M. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. Journal of applied physiology (Bethesda, Md.: 1985), 107(3), 987–992. 2009. https://doi.org/10.1152/japplphysiol.00076.2009

- TIPTON, K. & WOLFE, R.R. Exercise, protein metabolism, and muscle growth. International Journal of Sport Nutrition and Exercise Metabolism, 11 (1), pp. 109-132. 2001. Disponível em: https://doi.org/10.1123/ijsnem.11.1.109

- TOIGO, M., & BOUTELLIER, U. New fundamental resistance exercise determinants of molecular and cellular muscle adaptations. European journal of applied physiology, 97(6), 643–663. 2006. https://doi.org/10.1007/s00421-006-0238-1

- VIERCK, J., O'REILLY, B., HOSSNER, K., ANTONIO, J., BYRNE, K., BUCCI, L., & DODSON, M. Satellite cell regulation following myotrauma caused by resistance exercise. Cell biology international, 24(5), 263–272. 2000. https://doi.org/10.1006/cbir.2000.0499

- VOLEK, Jeff S et al. “Whey protein supplementation during resistance training augments lean body mass.” Journal of the American College of Nutrition vol. 32,2: 122-35. 2013. Disponível em: https://doi.org/10.1080/07315724.2013.793580

- YANG, S. Y., & GOLDSPINK, G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS letters, 522(1-3), 156–160. 2002. https://doi.org/10.1016/s0014-5793(02)02918-6

Published

2022-07-13

Issue

Section

Original Papers