Antiproliferative and anti-inflammatory activity from aerial parts of Psychotria cupularis (Rubiaceae) / Atividade antiproliferativa e anti-inflamatória das partes aéreas de Psychotria cupularis (Rubiaceae)

Authors

  • Matheus A. Peixoto
  • José G. S. Corrêa
  • Vagner M. de Moura
  • Juliana F. da Silva
  • Franciele Q. Ames
  • Armando M. Pomini
  • João E. de Carvalho
  • Ana Lúcia T. G. Ruiz
  • André M. A. Amorim
  • Ciomar A. Bersani-Amado
  • Silvana M. O. Santin

DOI:

https://doi.org/10.34117/bjdv6n9-234

Keywords:

Psychotria cupularis, Rubiaceae, anti-inflammatory activity, antiproliferative activity, phytochemical screening, pharmacology.

Abstract

The crude extract and fractions of aerial parts from Psychotria cupularis, collected at Camacan (Brazil), were tested for anti-inflammatory and antiproliferative activity. A phytochemical screening indicated the presence of tannins, anthraquinones, triterpenes, steroids and flavonoids. The crude extract and fractions inhibited the ear oedema in mice between 50.2 to 87.2% and the myeloperoxidase enzyme activity between 51.6 to 97.1%. The butanolic and ethyl acetate fractions was active against glioma, breast, ovary, kidney, colon and leukaemia cell line (IG50 = 4.3 to 16.9 ?g/mL).

 

 

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Published

2020-09-10

How to Cite

Peixoto, M. A., Corrêa, J. G. S., de Moura, V. M., da Silva, J. F., Ames, F. Q., Pomini, A. M., Carvalho, J. E. de, Ruiz, A. L. T. G., Amorim, A. M. A., Bersani-Amado, C. A., & Santin, S. M. O. (2020). Antiproliferative and anti-inflammatory activity from aerial parts of Psychotria cupularis (Rubiaceae) / Atividade antiproliferativa e anti-inflamatória das partes aéreas de Psychotria cupularis (Rubiaceae). Brazilian Journal of Development, 6(9), 67217–67228. https://doi.org/10.34117/bjdv6n9-234

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Original Papers