Análise da presença de benzodiazepínicos no ambiente aquático e o possível cenário de impacto ambiental / Analysis of the presence of benzodiazepines in the aquatic environment and the possible environmental impact scenario

Authors

  • Maria Virgínia Alves Ramalhão
  • Lara Luiza Freitas de Oliveira
  • Ralph Gruppi Thomé
  • Hélio Batista dos Santos
  • Magna Cristina de Paiva
  • Farah Maria Drumond Chequer

DOI:

https://doi.org/10.34117/bjdv7n10-315

Keywords:

Benzodiazepínicos, Efluentes, Esgoto, Águas residuais.

Abstract

Os benzodiazepínicos são fármacos psicotrópicos amplamente utilizados, que podem atingir o meio aquático por diversas vias e persistirem nestes ambientes como micropoluentes, devido aos processos de tratamento de água e esgoto convencionais não removerem os mesmos em sua totalidade. Dessa forma, foi realizada uma revisão narrativa com o objetivo de avaliar estudos que retratem a presença de benzodiazepínicos em ambientes aquáticos e suas respectivas concentrações, além de analisar os possíveis impactos negativos ao meio ambiente. Foram realizadas buscas de artigos, em quatro bases de dados: PubMed, Science Direct, SciELO e Google Acadêmico, utilizando os descritores “Sewage”, “Benzodiazepine”, “Effluents” e “Wastewater”, juntamente com o operador booleano “AND”. 34 artigos foram incluídos nesta revisão, sendo três realizados no Brasil e 31 em outros países. Foi observado que 32/34 artigos relataram a presença de benzodiazepínicos no ambiente aquático, sendo os mais frequentes o diazepam, oxazepam e lorazepam, e os encontrados em maiores concentraçoes o bromazepam, oxazepam e lorazepam. Dois estudos abordaram também alguns efeitos tóxicos decorrentes da presença de benzodiazepínicos no ambiente aquático, tais como citotoxicidade em leveduras e diatomáceas, bioacumulação e alterações comportamentais em peixes. A presença destes fármacos no ambiente aquático é preocupante, uma vez que os benzodiazepínicos podem causar danos não só aos organismos aquáticos, mas também à saúde pública. Portanto, a presente revisão coloca em foco a presença de benzodiazepínicos no ambiente aquático e seus efeitos nocivos, sendo necessários mais estudos de toxicidade e o desenvolvimento de novas tecnologias para resolução desta problemática.

 

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Published

2021-10-22

How to Cite

Ramalhão, M. V. A., de Oliveira, L. L. F., Thomé, R. G., dos Santos, H. B., de Paiva, M. C., & Chequer, F. M. D. (2021). Análise da presença de benzodiazepínicos no ambiente aquático e o possível cenário de impacto ambiental / Analysis of the presence of benzodiazepines in the aquatic environment and the possible environmental impact scenario. Brazilian Journal of Development, 7(10), 99377–99408. https://doi.org/10.34117/bjdv7n10-315

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