Cognition of infants exposed to Zika virus in pregnancy: a systematic review / Cognição de bebês expostos ao vírus zika na gestação: revisão sistemática

Authors

  • Samantha Nunes Santos Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Denise Miranda
  • Gúbio Soares Campos
  • Silvia Inês Sardi
  • Marina Martorelli Pinho
  • Nayara Argollo
  • Eduardo Pondé de Sena

DOI:

https://doi.org/10.34117/bjdv8n4-521

Keywords:

zika congenital syndrome, cognition, child development.

Abstract

This article aimed to systematically review the literature on the cognition of children exposed to Zika virus infection (ZIKV) during pregnancy. After searching the main electronic databases, PubMed, Capes, Web of Science, Scopus, Cochrane and BVS, the keywords “Zika virus”, “ZIKV infection”, “pregnancy”, “congenital”, “congenital syndrome”, “development”, “Cognition”, “neurodevelopment”, “child”, “infants”, “neuropsychology”, “developmental disorders”, “Bayley”, “Denver” were used for systematic data search. After applying the eligibility criteria for inclusion, 20 articles related to the cognitive assessment of children exposed to intrauterine ZIKV published until 2019 November, were selected. The systematic review identified the following as the main results: delayed cognition, motor skills, language and personal social domain, with worse performance in children with microcephaly or other severe brain injuries. Most normocephalic children exposed to ZIKV showed performance compatible with age. However, a smaller number of normocephalic children had a low score in at least one evaluated cognitive domain, characterizing specific developmental deficits. This review highlights the high risk of intrauterine ZIKV exposure to neurodevelopment and suggests investigating the cognitive development of all children exposed to ZIKV for long-term cognitive profiling, allowing early access to multidisciplinary rehabilitation programs.

References

ALVES, L.V. et al. Neurodevelopment of 24 children born in Brazil with congenital Zika syndrome in 2015: a case series study. BMJ Open, v. 8: e 021304, 2018.

BOTELHO, A. C. G. et al. Presumed congenital infection by Zika virus: findings on psychomotor development-a case report. Revista Brazileira de Saúde Materno Infantil., v. 16, Supl 1, p. 39-44, 2016.

BRAZIL (a). Ministry of Health, Epidemiological Bulletin v. 50 n 22, 2019: Monitoring of cases of urban arboviruses transmitted by Aedes (dengue, chikungunya and Zika) until Epidemiological Week 34 of 2019 https://portalarquivos2.saude.gov.br/images/pdf/2019/setembro/11 /BE-arbovirus-22.pdf . Accessed on 10.12.2019.

BRAZIL (b). Ministry of Health, Epidemiological Bulletin v. 50 nª 08, 2019: Integrated monitoring of changes in growth and development related to Zika virus infection and other infectious etiologies, until Epidemiological Week 52 of 2018. https://portalarquivos2.saude.gov.br/images/pdf/2019/marco/22/2019-001.pdf. Accessed on 10.12.2019.

CABRAL, J. et al. Neurodevelopmental delays arising from in utero exposure to Zika virus in Salvador, Brazil. International Journal of Infectious Diseases, v. 73, n. 48-9, 2018.

CARDOSO, T. F. et al. Congenital Zika infection: neurology can occur without microcephaly. Arch Dis Child, v. 104, n. 2, p. 199–200, 2019.

CARVALHO, A. et al. Clinical and neurodevelopmental features in children with cerebral palsy and probable congenital Zika. Brain Dev v. 41, n. 7, p. 587-594, 2019a. https://doi.org/10.1016/j.braindev.2019.03.005.

CARVALHO, A. L. et al. Cerebral palsy in children with congenital Zika Syndrome: A 2-year neurodevelopmental follow-up. J Child Neurol., v. 35, n. 3, p. 202-207, 2019b, Nov. 13:883073819885724.

CENTERS FOR DISEASE CONTROL AND PREVENTION. Travel health notices. Centers for Disease Control and Prevention; 2016. Disponível em: http://wwwnc. cdc.gov/travel/notices. Accessed: October 17, 2016.

COSTA, F. et al. Emergence of congenital Zika syndrome: viewpoint from the front lines. Ann Intern Med., v. 164, n. 10, p. 689–69, 2016.

EBRAHIM, S.; CLARKE, M. STROBE: new standards for reporting observational epidemiology, a chance to improve. Int J Epidemiol, v. 36, n. 5, p. 946-948, 2007.

EINSPIELER, C. et al. Association of infants exposed to prenatal Zika virus infection with their clinical, neurologic, and developmental status evaluated via the general movement assessment tool. JAMA Network Open, v. 2, n. 1, Jan. 2019.

FAIÇAL, A. V. et al. Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus. BMJ Paediatr Open., v. 3, n. 1, e000486, 2019. doi:10.1136/ bmjpo-2019-000486.

FERREIRA, H. N. C. et al. Functioning and disability profile of children whit microcephaly associated whith congenital Zika virus infection. Int J. Environ Res. Public Health., v. 15, n. 6 1107, 2018.

FLOR, C.J.D.R.V.; GUERREIRO, C. F.; ANJOS, J. L. M. Neuropsychomotor development in children with microcephaly associated with Zika Virus. Revista Pesquisa em Fisioterapia, v. 7, n. 3, p. 313-318, 2017.

FRANÇA, G. V. A. et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation Lancet., v. 388, n. 10047, p 891-897, 2016 Aug. 27.

LOPES MOREIRA, M. E. et al. Neurodevelopment in infants exposed to Zika virus in utero. N Engl J Med., v. 379, n. 24, p. 2377-9, 2018.

MARQUES, F. J. P. et al. Children born with congenital Zika Syndrome display atypical gross motor development and a higher risk for cerebral palsy. J. Child Neurol., v. 34, n. 2, p. 81-85, 2019.

MUSSO, D.; STRAMER, S. L.; BUSCH, M. P. Zika virus: a new challenge for blood transfusion. Lancet, v. 387, p. 1993–1994, 2016.

NIELSEN-SAINES, K. et al. Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nature Medicine, v. 25, p. 1213-1217, Aug. 2019.

PANCHAUD, A. et al. Emerging role of Zika virus in adverse fetal and neonatal outcomes. Clin Microbiol Rev., v, 29, n. 3, p. 659–694, 2016.

PETERSEN, E. E. et al. Update: interim guidance for preconception counseling and prevention of sexual transmission of Zika virus for persons with possible Zika virus exposure—United States, September 2016. MMWR Morb Mortal Wkly Rep., v, 65, n. 39, p, 1077–1081, 2016.

PRATA-BARBOSA, A.; MARTINS, M. M.; GUASTAVINO, A. B.; CUNHA, A. J. Effects of Zika infection on growth. J Pediatr (Rio J)., v. 95, p. S30-S41, 2019.

SOARES-MARANGONI, D. A. et al. General movements and motor outcomes in two infants exposed to Zika virus: brief report [published online February 16, 2018] Dev Neurorehabi, v. 1; p. 71-74, 2019.

SUBISSI, L. et al. Zika virus infection during pregnancy and effects on early childhood development, French Polynesia, 2013-2016. Emerging infectious diseases, v. 24, n. 10, p. 1850–1858, 2018. doi:10.3201/eid2410.172079.

VALDES, V. et al. Cognitive development of infants exposed to the Zika virus in Puerto Rico. JAMA Netw Open., v. 2, n. 10, :e1914061, 2019 Oct. 2.

WHEELER, A. et al. Skills attained by infants with congenital Zika syndrome: Pilot data from Brazil. Vijavaprasad Gopichandran, Ed. Plos One, v. 13, n. 7. e 0201495, 2018.

ZANCANELLI, A. M. Gestational infection by Zika Virus: motor development in the first years of life, environmental context and epidemiological profile. 2018. 103 f. Dissertation (Master's in Rehabilitation Sciences and Physical-Functional Performance) - Federal University of Juiz de Fora (UFJF). Juiz de Fora, 2018. Available at: https://repositorio.ufjf.br/jspui/handle/ufjf/7234. Accessed on: 19 Jul. 2018.

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Published

2022-04-26

How to Cite

Santos, S. N., Miranda, D., Campos, G. S., Sardi, S. I., Pinho, M. M., Argollo, N., & Sena, E. P. de. (2022). Cognition of infants exposed to Zika virus in pregnancy: a systematic review / Cognição de bebês expostos ao vírus zika na gestação: revisão sistemática. Brazilian Journal of Development, 8(4), 30763–30778. https://doi.org/10.34117/bjdv8n4-521

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Section

Original Papers